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Glutathione deficiency and Parkinson's disease -- Cause and Treatment.
2006-10-17
Parkinson's Disease is one of the most disabling disorders in the world and it significantly shortens the lives of those effected. It is a neurological disorder that is characterized by shaking tremors, weakness, stiffness and rigidity. Mental ability decreases and such simple tasks as walking and starting movement can become impossible. The cause of the degeneration has for many years been a mystery, but researchers have described that the Substantia Nigra section of the brain loses its function. Dopamine, a neurotransmitter that helps connect, or carry signals from one neuron to another, decreases significantly and the process worsens.
 
Typically the treatment regimens have tried to help replenish Dopamine and help decrease tremors but, the results are generally mixed.

In the Nutritional realm over the past decade or so, researchers were looking further into the disease and tried to understand the biochemical process a bit better. Over time, as with many other degenerative diseases, they were looking at oxidative stress as a contributor to the brain degeneration. With an understanding of free radical pathology and antioxidant benefit, the focus switched to helping to stop oxidative damage. Researchers soon found themselves looking at Glutathione levels in effected tissues and found them to be depleted. Is this a possible cause of the disease? Might this lead to a new line of reasoning and new treatment?

 
Well, it does seem that Glutathione is extremely important to the brain, and especially the Substantia Nigra. It probably has a lot to do with the disease.
More importantly, therapy with Glutathione intravenously has shown some very significant results. In a variety of institutions (as well as in my office), IV treatment has helped to change the course of this disease. Patients that are having difficulty with movement are doing much better, tremors have become far less obvious, and we've noticed improvement in memory and concentration. Weakness, stiffness and balance have improved greatly as well.
 
The treatment needs to be done 2 - 3 times a week, and results are usually seen within a week or so. Intravenous access is necessary because it carries with it 100% absorption of product. Oral forms of Glutathione are not absorbed well at all. Results have been seen only with the intravenous technique.
The attached articles support this view.
 
Looking at diseases with a "nutritional eye" has always yielded new pathways to follow and new, viable techniques of treatment.
 
Stay tuned for more surprising info!!
 
Dr. Chris Calapai

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